Scaling graphs of heart rate time series in athletes demonstrate the VLF, LF and HF regions

Scaling analysis of heart rate time series has emerged as an useful tool for assessment of autonomic cardiac control. We investigate the heart rate time series of ten athletes (five males and five females), by applying detrended fluctuation analysis (DFA). High resolution ECGs are recorded under standardized resting conditions over 30 minutes and subsequently heart rate time series are extracted and artefacts filtered. We find three distinct regions of scale-invariance, which correspond to the well-known VLF, LF, and HF bands in the power spectra of heart rate variability. The scaling exponents alpha are alphaHF: 1.15 [0.96-1.22], alphaLF: 0.68 [0.57-0.84], alphaVLF: 0.83[0.82-0.99]; p<10^-5). In conclusion, DFA scaling exponents of heart rate time series should be fitted to the VLF, LF, and HF ranges, respectively

Secretion and assembly of functional mini-cellulosomes from synthetic chromosomal operons in Clostridium acetobutylicum ATCC 824.

Background: Consolidated bioprocessing (CBP) is reliant on the simultaneous enzyme production, saccharification of biomass, and fermentation of released sugars into valuable products such as butanol. Clostridial species that produce butanol are, however, unable to grow on crystalline cellulose. In contrast, those saccharolytic species that produce predominantly ethanol, such as Clostridium thermocellum and Clostridium cellulolyticum, degrade crystalline cellulose with high efficiency due to their possession of a multienzyme complex termed the cellulosome. This has led to studies directed at endowing butanol-producing species with the genetic potential to produce a cellulosome, albeit by localising the necessary transgenes to unstable autonomous plasmids. Here we have explored the potential of our previously described Allele-Coupled Exchange (ACE) technology for creating strains of the butanol producing species Clostridium acetobutylicum in which the genes encoding the various cellulosome components are stably integrated into the genome. Results: We used BioBrick2 (BB2) standardised parts to assemble a range of synthetic genes encoding C. thermocellum cellulosomal scaffoldin proteins (CipA variants) and glycoside hydrolases (GHs, Cel8A, Cel9B, Cel48S and Cel9K) as well as synthetic cellulosomal operons that direct the synthesis of Cel8A, Cel9B and a truncated form of CipA. All synthetic genes and operons were integrated into the C. acetobutylicum genome using the recently developed ACE technology. Heterologous protein expression levels and mini-cellulosome self-assembly were assayed by western blot and native PAGE analysis. Conclusions: We demonstrate the successful expression, secretion and self-assembly of cellulosomal subunits by the recombinant C. acetobutylicum strains, providing a platform for the construction of novel cellulosomes. © 2013 Kovács et al.; licensee BioMed Central Ltd

Solar total irradiance in cycle 23

The apparently unusual behaviour of the TSI during the most recent minimum of solar activity has been interpreted as evidence against solar surface magnetism as the main driver of the secular change in the TSI. We test claims that the evolution of the solar surface magnetic field does not reproduce the observed TSI in cycle 23. We use sensitive, 60-minute averaged MDI magnetograms and quasi-simultaneous continuum images as an input to our SATIRE-S model and calculate the TSI variation over cycle 23, sampled roughly twice-monthly. The computed TSI is then compared to the PMOD composite of TSI measurements and to the data from two individual instruments, SORCE/TIM and UARS/ACRIM II, that monitored the TSI during the declining phase of cycle 23 and over the previous minimum in 1996, respectively. Excellent agreement is found between the trends shown by the model and almost all sets of measurements. The only exception is the early, i.e. 1996 to 1998, PMOD data. Whereas the agreement between the model and the PMOD composite over the period 1999-2009 is almost perfect, the modelled TSI shows a steeper increase between 1996 and 1999 than implied by the PMOD composite. On the other hand, the steeper trend in the model agrees remarkably well with the ACRIM II data. A closer look at the VIRGO data, that make the basis of the PMOD composite after 1996, reveals that only one of the two VIRGO instruments, the PMO6V, shows the shallower trend present in the composite, whereas the DIARAD measurements indicate a steeper trend. We conclude that (1) the sensitivity changes of the PMO6V radiometers within VIRGO during the first two years have very likely not been correctly evaluated, and that (2) the TSI variations over cycle 23 and the change in the TSI levels between the minima in 1996 and 2008 are consistent with the solar surface magnetism mechanism

Simulating spatial and temporal evolution of multiple wing cracks around faults in crystalline basement rocks

Fault zones are structurally highly spatially heterogeneous and hence extremely complex. Observations of fluid flow through fault zones over several scales show that this structural complexity is reflected in the hydrogeological properties of faults. Information on faults at depth is scarce, hence, it is highly valuable to understand the controls on spatial and temporal fault zone development. In this paper we increase our understanding of fault damage zone development in crystalline rocks by dynamically simulating the growth of single and multiple splay fractures produced from failure on a pre-existing fault. We present a new simulation model, MOPEDZ (Modeling Of Permeability Evolution in the Damage Zone surrounding faults), that simulates fault evolution through solution of Navier's equation with a combined Mohr-Coulomb and tensile failure criteria. Simulations suggest that location, frequency, mode of failure and orientation of splay fractures are significantly affected both by the orientation of the fault with respect to the maximum principal compressive stress and the conditions of differential stress. Model predictions compare well with published field outcrop data, confirming that this model produces realistic damage zone geometries

ACRIM-gap and total solar irradiance revisited: Is there a secular trend between 1986 and 1996?

A gap in the total solar irradiance (TSI) measurements between ACRIM-1 and ACRIM-2 led to the ongoing debate on the presence or not of a secular trend between the minima preceding cycles 22 (in 1986) and 23 (1996). It was recently proposed to use the SATIRE model of solar irradiance variations to bridge this gap. When doing this, it is important to use the appropriate SATIRE-based reconstruction, which we do here, employing a reconstruction based on magnetograms. The accuracy of this model on months to years timescales is significantly higher than that of a model developed for long-term reconstructions used by the ACRIM team for such an analysis. The constructed `mixed' ACRIM - SATIRE composite shows no increase in the TSI from 1986 to 1996, in contrast to the ACRIM TSI composite.Comment: 4 figure

Call and Response: SEM President’s Roundtable 2016, “Ethnomusicological Responses to the Contemporary Dynamics of Migrants and Refugees”

The privilege of organizing the SEM President’s Roundtable in 2016 and 2017 provided an opportunity to call attention to a topic that has concerned my teaching and research since graduate school. For the first iteration of “Ethnomusicological Responses to the Contemporary Dynamics of Migrants and Refugees” I convened a panel of people whose perspectives I admire. I wanted to learn from them, and I did. As someone who has been involved with Middle Eastern and more specifically Arab music and culture within my own academic and regional community, I was making new efforts in the fall of 2016 toward engaged ethnomusicology in Virginia among my own newest neighbors, and organizing this SEM President’s Roundtable gave me courage and inspiration. Our “Call and Response” presents snapshots from five colleagues who are engaged with communities of migrants and refugees in Africa, the Middle East, Europe, and North America..